Dolly Parton, who has been married for over 45 years, has not been able to have children. This inability to have kids has been a source of depression for her.

Oscar-winner Dame Helen Mirren became a stepmother when she married a father of two in 1997, but she has openly stated that she possesses “no maternal instinct whatsoever.”

Former Secretary of State Condoleezza Rice has never married or had children.

Oprah Winfrey endured a traumatic experience during her childhood and became pregnant at the age of 14.

In an effort to conceal the pregnancy from her father, who expressed strong disapproval, she even attempted to abort the baby by drinking bleach. Sadly, her premature son did not survive long after birth, and Oprah has not had any children since.

This personal story was disclosed when a family member shared the information in 1990.

Talk show host Jay Leno has been married to his wife Mavis since 1980, but they do not have any children.

Actress Lily Tomlin married her longtime partner, Jane Wagner, in 2013, and the couple does not have any children.

Chicago star Renee Zellweger, despite her divorce and relationships with Jack White, Jim Carrey, and Bradley Cooper, does not have any children.

Beetlejuice star Winona Ryder, who has had relationships with Johnny Depp and Matt Damon, has not had any children.

Comedian Chelsea Handler dated Comcast Entertainment Group CEO Ted Harbert for an extended period, but she has never had children.

Actress Katharine Hepburn dated Spencer Tracy for many years but never had children.

Talk show host, actress, and rapper Queen Latifah has never married or had children.

“Sex and the City” star Kim Cattrall has been married three times, but she has never had any children.

“The Office” creator Ricky Gervais has been in a relationship with Jane Fallon for 31 years. As an outspoken atheist, Gervais believes that having a wedding ceremony in front of God is pointless, given his atheistic beliefs.

He also has no desire to have children, citing concerns about dedicating 16 years of his life to parenting and a belief that there are already too many children in the world.

Bo Derek was married to John Derek for many years and later became involved with actor John Corbett after John Derek’s passing. She does not have any children but has a deep affection for horses.

Diane Sawyer married “The Graduate” director Mike Nichols in 1988. Although they didn’t have any children together, Nichols had three children from a previous marriage.

Actress Jennifer Aniston is frequently the subject of media speculation regarding a potential pregnancy, but to date, she has not had any children.

“The Wrestler” actor Mickey Rourke considers his dogs as his children and attributes them with saving his life. Rourke shared a moment when he contemplated suicide, but his dog, Beau Jack, made a human-like sound, which deeply affected him. He expressed that since he doesn’t have children, his dogs have become everything to him, and their needs became a driving force to keep him going.

Megan Mullally and her husband, “Parks and Recreation” star Nick Offerman, have been married since 2003 and do not have children.

Actor Matt Dillon has never married and has not had any children.

Ashley Judd was married to Dario Franchitti from 2001 to 2013, but the couple did not have any children.

On the topic, Judd expressed that she believed it would be unconscionable to have children given the number of children in impoverished countries who are suffering from starvation.

Celebrity chef Rachael Ray has been married to John Cusimano since 2005, but they do not have any children.

“Casino” star James Woods has been married twice but does not have any children.

“The Royal Tenenbaums” star Anjelica Huston had a relationship with Jack Nicholson from 1973 to 1989 and was married to sculptor Robert Graham from 1992 until his death in 2008. However, she does not have any children.

Patrick Swayze and his wife, Lisa Niemi, were married from 1975 until his passing, but they never had children. They shared a love for ranching, breeding Arabian horses, caring for cattle, and keeping several dogs on their ranches in California and New Mexico.

Swayze sadly passed away in September 2009, just 20 months after being diagnosed with pancreatic cancer.

Ann-Margret was unable to have children of her own but became a stepmother to her late husband Roger Smith’s three children.

Jon Hamm dated “Friends with Kids” star/director Jennifer Westfeldt from 1997 to 2015. He has expressed the belief that people should not get married until they are prepared to have children.

Ellen DeGeneres and her wife, Portia de Rossi, do not have any children.

“Archer” actress Aisha Tyler emotionally revealed on her talk show that she has a condition preventing her from getting pregnant. She was married to Jeff Tietjens from 1992 until 2017.

Singer Liza Minnelli was pregnant once but did not have any children. She has gone through four divorces.